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KMID : 0370220120560020099
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Yakhak Hoeji
2012 Volume.56 No. 2 p.99 ~ p.107
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Hepatoprotecive Effects of Alnus japonica Extract on Experimental Liver Injury Models
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Zhao Yu-Zhe
Lee Sung-Hee
Huh Jae-Wook
Ra Jeong-Chan
Sohn Dong-Hwan
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Abstract
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The protective effect of AI-1367 (Alnus japonica extract) on liver injury was investigated. Primary rat hepatocyte intoxication was induced by tert-butyl hydroperoxide (tBH), carbon tetrachloride (), or D-glactosamine (D-GalN). Liver injury was induced by , D-GalN or MCD (methionine choline deficient)-diet in mouse. The cellular leakage of lactate dehyrogenase and cell viability followed by the treatment of hepatotoxicants were significantly improved by AI-1367 treatment at a concentration range of 5~50 for tBH, 5~50 for D-GalN, and 5~100 for , respectively. Treatment with AI-1367 (20, 10, 5 mg/kg, p.o.) on liver injury induced by subcutaneous injection of or D-GalN reduced significantly the levels of aspartate transaminase and alanine transaminase in serum. Histological observations revealed that fatty acid changes, hepatocyte necrosis and inflammatory cell infiltration in (D-GalN)-induced liver injury was improved by administration of AI-1367. AI-1367 treatment (10, 5, 2.5 mg/kg, p.o.) also significantly recovered the body weight change and serum levels of aspartate transaminase, alanine transaminase and triglyceride in liver injury induced by MCD diet. From these results, AI-1367 shows protective effects against tBH, , D-GalN, or MCD diet-induced hepatotoxicity in vitro or in vivo.
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KEYWORD
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Alnus japonica, hepatocyte, MCD diet, , D-GalN, hepatoprotective
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